Pharma Intermediates Oestradiol/Estradiol/Test Steroids Powder for Female Sex Hormone 50-28-2

Pharma Intermediates Oestradiol/Estradiol/Test Steroids Powder for Female CAS 50-28-2What is Estradiol Powder?Estradiol (E2 or 17β-estradiol, also oestradiol) is a sex hormone. Estradiol is abbreviated E2 as it has twohydroxyl groups in its molecular structure. Estrone has one (E1) and estriol has three (E3). Estradiol is about 10 times as potent as estrone and about 80 times as potent as estriol in its estrogenic effect. Except during the early follicular phase of the menstrual cycle, its serum levels are somewhat higher than that of estrone during the reproductive years of the human female. Thus it is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity. During menopause, estrone is the predominant circulating estrogen and during pregnancy estriol is the predominant circulatingestrogen in terms of serum levels. The serum levels of estradiol in males (14 - 55 pg/mL) are roughly comparable to those of postmenopausal women (< 35 pg/mL). Estradiol in vivo is interconvertible with estrone; estradiol to estrone conversion being favored. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones.
Certificate of Analysis
product name
estradiol
cas no.
50-28-2
mfg date
2019-01-28
report date
2019-01-29
batch no.
20190128
expiry date
2021-1-27
quantity
100.0kg
reference standard
usp36
subjects
specification
results
appearance
white or almost white crystalline powder
white crystalline powder
optical rotation
+76°~+83°
+77.58°
melting point
173~179°c
174.5~177.5°c
identification
ir
uv
conform
conform
impurities
single impurity≤0.5%
total impurities≤1.0%
<0.5%
<1.0%
water
≤3.5%
3.05%
assay
97.0%~103.0%
98.62%
conclusion
the products meet the specification of usp36.Funtion of Estradiol
1.Endometrial hyperplasia
2.To enhance uterine contraction of the smooth muscle
3.Breast duct hyperplasia to development
4.Androgen depriation role
5.To lower blood cholesterol
6.To increase the bone of calcium in calmApplicationof Estradiol1-Applied in pharmaceutical field, Estradiol is used as Endocrine System Agents;
2-Applied in Chemicial field, Estradiol can be used as Auxiliaries and Other Medicine Chemicals.

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