Diclofenac Sodium Gel for relieving mild and moderate pain for muscle, soft tissue and joint

Diclofenac Sodium Gel
Generic name: Diclofenac Sodium Gel
Brand name: ANTINE
Composition: The chemical name is 2-[(2,6-dichlorophenyl) amino]benzene- acetic acid, monosodium salt.
The molecular weight is 318.14. Its molecular formula is C14H10Cl2NNaO2Description:This product is water soluble gel .
Strength:1%/15g, 1%/20gIndications:
It is indicated for relieving mild and moderate pain for muscle, soft tissue and joint.For example , it can relieve
pain of muscle and soft tissue caused by sprain, pull, bruise, strain and damage of waist and back, as well as
joint pain. Meanwhile it can be used for symptomatic treatment for osteoarthritis.
Dosage and administration:
For external use only. The proper product can be used to be gently applied on skin as per area of pain, so
that the product can be penetrated into the skin, 3~4 times daily.Precautions:
Cardiovascular Thrombotic Events
Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown
an increased risk of serious cardiovascular (CV) thrombotic events, includingmyocardial infarction (MI) and
stroke, which can be fatal. based on available data, it is unclear that the risk for CV thrombotic events is
similar for all NSAIDs. The relative increase in serious CV thrombotic events over baseline conferred NSAID
use appears to be similar in those withand without known CV disease or risk factors for CV disease. However
patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thromb-
otic events, due to their increased baseline rate.
Some observational studies found that this increased risk of serious CV thrombotic events began as early as
the first weeks of treatment. The increase in CV thrombotic risk has been observed most consistently at
higher doses.To minimize the potential risk for an adverse CV event in NSAID-treated patients, use the
lowesteffective dose for the shortest duration possible. Physicians and patients should remain alert for the
development of such events, throughout the entire treatment course, even in the absence of previous CV
symptoms. Patients should be informed about the symptoms of serious CV events and the steps to take if
they occur.There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of
serious CV thrombotic events associated with NSAID use. The concurrent use of aspirin and an NSAID, such
as diclofenac, increases the risk of serious gastrointestinal (GI) events .
Pharmacology and toxicology:
This product is a prostaglandin synthesis inhibitor, which has the effect of anti-inflammatory and analgesic.
Local application, its effective component can penetrate the skin to reach the area of inflammation, relieve
acute and chronic inflammatory reactions, reduce inflammatory pain and relieve pain.
Storage:Protect from light, and keep air-tightly.
Packs:Package material: 1tube/Box
Shelf-life:24 months