Hirudin Leech Hirudin Leech Hirudin Powder

Best Price leech hirudin powder for medical purposesProduct Description
Other Name: Pharmaceutical hirudin, Dried Leech Extract
Appearance: Brown Yellow Powder
Specification: 98%
CAS No.: 113274-56-9
MF: C66H93N13O25
MOQ: 1kg
Functions: Treating a variety of thrombotic diseases
Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property. This is fundamental for the leeches’ alimentary habit of hematophagy, since it keeps the blood flowing after the initial phlebotomy performed by the worm on the host’s skin.A key event in the final stages of blood coagulation is the convertion of fibrinogen into fibrin by the serine protease enzyme thrombin.Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in normal blood circulation is antithrombin III.Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the pro-coagulant activity of thrombin.Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin binds to and inhibits only the activity of thrombin forms with a specific activity against fibrinogen.Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.
Function
1.Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property. This is fundamental for the leeches’ alimentary habit of hematophagy, since it keeps the blood flowing after the initial phlebotomy performed by the worm on the host’s skin.
2.Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in normal blood circulation is antithrombin III.
3.Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the pro-coagulant activity of thrombin.Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin binds to and inhibits only the activity of thrombin forms with a specific activity against fibrinogen.
4.Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, as a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.

Application
1. Hirudin is a promising anticoagulant and antispasmodic drug that can be used to treat various thrombotic diseases, especially venous thrombosis and diffuse vascular coagulation.
2. Hirudin can be used to prevent the formation of arterial thrombosis after surgery, to prevent the formation of thrombus after thrombolysis or revascularization; to improve the blood circulation and hemodialysis process in vitro.
3. Hirudin often fails in microsurgery due to vascular embolization at the anastomosis. Hirudin can promote wound healing. Studies have also shown that hirudin can also play a role in cancer treatment.
4. Hirudin can prevent the metastasis of tumor cells, and has proven therapeutic tumors such as fibrosarcoma, osteosarcoma, angiosarcoma, melanoma and leukemia.
5. Hirudin can also be combined with chemotherapy and radiation therapy to enhance the effect of blood flow in the tumor.Packaging & Shipping
Safe, Secure Packaging -Full sealed
1g/bottle, 5g/bottle, 10g/bottle, 100g/bottle or upon customer's request
1-25kgs:Aluminium bag outside and double plastic bags inside
More than 25kgs:Fiber drum outside and plastic bags inside
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Suitable for under 25kg
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Suitable for more than 25kg
Fast: 3-7 days
Suitable for more than 500kg
Slow: 7-15 daysOur Services
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