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China Beijing Medical Diagnostic Test Kits Pregnendione Elisa Reagent Kit
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Product nameDetection Kit for Progesterone(P)( ELISA)beijing,chinaMethodologyEnzyme-linked immunosorbent assay
Size
3.0mm/3.5mm
Storage
2-8℃ at room temperature
Shelf life
12-18Months
Brand Name
BNIBT
MOQ
50 boxes
Certification
CFDAAccuracyOver 99%Detection range40μIU/ml to 2000μIU/mlIncubation1 hSample volume50μlPayment methodT/T, Western Union or Paypal are availableDelivery time3--25 days(As your order)Free samplesAvailableOther ServiceThe kits can be made according to the customers' artwork or design.
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Clinical significance:
Human pituitary prolactin (PRL) is a 199 aminoacid protein produced by the lactotrophs of the anterior pituitary gland. A small proportion of pituitary PRL is glycosylated. PRL is secreted in an episodic mode, secretion is controlled negatively by dopamine.
Due to the pulsatile mode of PRL secretion and its susceptibility to stress, mild to moderate hyperprolactinemia necessitates a double check to confirm that PRL level is truly abnormal. When this is /confirm/ied, one should investigates various and frequent causes of moderately abnormal PRL, such as pregnangy, untreated hypothyroidism, chronic renal failure and cirrhosis. Many widely used drugs create hyperprolactinemia: among them, chlorpromazin, fluphenazin, haloperidol, metoclopramide, sulpiride, methyldopa, reserpine, verapramil, opiates, cimetidine and not systematically, estrogens. Neuro-hypothalamic diseases can also be responsible for mild to moderate hyperprolactinemia: tumors, cysts, metastasis, infiltrative diseases (sarcoidosis, tuberculosis, histiocytosis X), brain atrophy either senile or secondary to brain damage due to anoxia. Whatever the etiology, hyperprolactinemia can produce gonadal dysfunction in both sexes through impairment of gonadotropin secretions.
Significant hyperprolactinemia justifies immediate investigation to determine weither it is a secondary phenomenon or due primarily to a PRL secreting pituitary tumor.
Prolactinoma is the most common type of pituitary adenoma. It can be either sporadic or belong to a multiple endocrine neoplasia syndrome, type 1. The most frequent clinical features are hypogonadism and infertility. Women experience irregularities in menstrual cycle, anovulation and finally amenorrhea. Galactorrhea is present in up to 60% of these patients but may last for a short period of time in the clinical history. The other features of estrogen deficiency are also present. Men suffer from partial or total hypogonadism and/or infertility. Gynecomastia and galactorrhea occur also frequently, in up to 30% of men with massive hyperprolactinemia .
Mixed pituitary adenoma, secreting GH and PRL, GH-TSH and PRL, ACTH and PRL have also been described. Clinical pictures are dominated by the leading dyssecretion but mixed clinical situations can be observed.
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