Urolithin A CAS 1143-70-0

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Urolithins are microflora human metabolites of dietary ellagic acid derivatives[1] such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate,[2] strawberries, red raspberries, walnuts or oak-aged red wine.[3]During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans.[2][4] Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice.[5]Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites. Urolithins are found in plasma mostly as glucuronides at low concentrations.[6]Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella.[7]Urolithin M7 has also been synthetized from 2-hydroxy-4-methoxybenzaldehyde using the inverse electron-demand Diels–Alder reaction.[8]



In laboratory studies, urolithin A was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging.[15] This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).[15]
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Wuhan HengHeDa Pharm Co., Ltd is a hi-tech enterprise locates in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. HengHeDa Pharm has complete administration management and a good work team, which makes it growing fast in chemicals and pharmaceutical industry.
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1. Who we are?Wuhan hengheda pharm Co., Ltd., located in Wuhan, China, was founded in the year of 2013 by Dr. ZhouWe are now the few professional manufacturers for the series of natural high purity product, such as astragalus extract (Astragaloside IV and Cycloastragenol), Gardenia jasminoides Ellis extract (Genipin, Geniposide and Geniposidic acid) and Galangin in China.Dr Zhou majored in natural plant chemistry and new chemical synthesis , who was graduated from Shanghai Institute of Biology, Chinese Academy of Science.)2. Do we have the test reports for our products provided by the independent third party?Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too.3. What is our advantage?The series of natural extracted product are all self-developed, produced and tested. Mature production technology, strict cost control, and perfect quality assurance system, ensure the product stability and competitive price.4. How we perform an order?Email inquiry is preferred in our company. We usually give our formal quotation list or formal reply within 24 hours including price, lead time and any other information customer needed. Our quotation is usually valid for three months.5. What is the minimum order quantity?No matter how much do you need, we all can supply you with the suitable package, from sample quantity to bulk order.