research chemical trans-ISRIB CAS 548470-11-7 98%

Product Description
ISRIB, (an acronym forIntegrated Stress Response Inhibitor), is an experimental drug which reverses the effects of eIF2α phosphorylation with an IC50of 5nM. It was discovered by a group atUCSFthrough a semi-automated screening of a large library of small molecules.It has also been shown to inhibit eIF2α phosphorylation-inducedstress granule(SG) formation.Since eIF2α phosphorylation is known to be involved in memory formation, ISRIB was tested to see whether it would be active, and was found to readily cross theblood-brain barrier, with a half-life of 8 hours. Subsequent testing in 2013 found ISRIB to produce significantnootropiceffects in mice, as measured by enhancement of spatial and fear-associated learning in standardwater mazeand conditioned environment tests. Testing in 2017 indicated the experimental drug improved the ability of brain-injured mice to learn and form memories on memory tests, thus appearing to reverse impairments from traumatic brain injury.Packaging & Shipping
Packaging Detail: 1. 10,50g,100g,500g,1kg in aluminum foil bags & 25kg/barrel.
2. The packaging can be on request
Delivery Detail: 5-7days for regular shipping
7-15days if shipping get delayedOur Services
1.Packing on request
2.Labeling on request
3.Shipping on request
4.HPLC,HNRM,LC-MS provided along with order
5.Custom synthesis acceptedCompany Information
Wuhan HengHeDa Pharm Co., Ltd is a hi-tech enterprise locates in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. HengHeDa Pharm has complete administration management and a good work team, which makes it growing fast in chemicals and pharmaceutical industry.
HengHeDa Pharm has a novel R&D center with advanced ventilation equipments and modern experiment equipments; we offer friendly working environment, have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of this makes us provide good quality products with high rating.
HengHeDa Pharm follows the principle of “quality first, customer above and credit fundamentality”, wishing to offer the best products to our customers.Contact us
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