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Name
Mannitol
OtherName
D-Mannitol
CASNo.
87-78-5
Assay
99%
Appearance
WhiteCrystallinePowder
Mannitolis a type ofsugar alcoholwhich is also used as a medication.As a sugar, it is often used as asweetenerindiabetic food, as it is poorly absorbed from theintestines.As a medication, it is used to decrease pressure in the eyes, as inglaucoma, and to lowerincreased intracranial pressure.Medically, it is given by injection.Effects typically begin within 15 minutes and last up to 8 hours
Product Name
Mannitol
Mfg. Date
2018.04.20
Batch No.
PBG20180420
Testing Date
2018.04.20Items
Specifications
ResultsMedical uses
Mannitol is used to reduce acutely raised intracranial pressure until more definitive treatment can be applied, e.g., afterhead trauma.
It may also be used for certain cases ofkidney failure with low urine output, decreasingpressure in the eye, to increase the elimination of certain toxins, and to treatfluid build up.
Mannitol acts as an osmoticlaxativein oral doses larger than 20 g,and is sometimes sold as a laxative for children..
Mannitol is commonly used in the circuit prime of aheart lung machineduringcardiopulmonary bypass. The presence of mannitol preserves renal function during the times of low blood flow and pressure, while the patient is on bypass. The solution prevents the swelling ofendothelial cellsin the kidney, which may have otherwise reduced blood flow to this area and resulted in cell damage.
Mannitol can also be used to temporarily encapsulate a sharp object (such as a helix on a lead for anartificial pacemaker) while it is passed through the venous system. Because the mannitol dissolves readily in blood, the sharp point will become exposed at its destination.
Mannitol is also the first drug of choice for the treatment of acuteglaucomain veterinary medicine. It is administered as a 20% solution intravenously. It dehydrates thevitreous humorand, therefore, lowers the intraocular pressure. However, it requires an intact blood-ocular barrier to work.Food
Mannitol increases blood glucose to a lesser extent thansucrose(thus having a relatively lowglycemic index) so is used as asweetenerfor people withdiabetes, and inchewing gums. Although mannitol has a higherheat of solutionthan most sugar alcohols, its comparatively low solubility reduces the cooling effect usually found in mint candies and gums. However, when mannitol is completely dissolved in a product, it induces a strong cooling effect.Also, it has a very lowhygroscopicity– it does not pick up water from the air until the humidity level is 98%. This makes mannitol very useful as a coating for hard candies, dried fruits, and chewing gums, and it is often included as an ingredient in candies and chewing gum.The pleasant taste and mouthfeel of mannitol also makes it a popularexcipientfor chewable tablets.Analytical chemistry
Mannitol can be used to form a complex withboric acid. This increases the acid strength of the boric acid, permitting better precision in volumetric analysis of this acid.Other
Mannitol is the primary ingredient ofmannitol salt agar, a bacterial growth medium, and is used in others.
Mannitol is popularly used as acutting agentin .